Academic Press

Other ISBN ranges for Academic Press: Academic Press (978-0-906187-...) · Academic Press (978-1-4832-...) · Academic Press (978-91-970020-...)

ISBN 978-0-12-249930-2 to 978-0-12-260502-4 < ISBN 978-0-12-260550-5 to 978-0-12-266975-0 > ISBN 978-0-12-266980-4 to 978-0-12-278001-1

year of pub­li­ca­ti­onISBNauthor(s)title
1978978-0-12-260550-5John L. Fletcher · R. G. BusnelEffects of Noise on Wildlife
1985978-0-12-260560-4Madilyn FletcherBacteria in Their Natural Environments (Society for General Microbiology Special Publications Series, Vol. 16)
  ''978-0-12-260561-1Madilyn FletcherBacteria in Their Natural Environments (Society for General Microbiology, Special)
1969978-0-12-260650-2Roger FletcherOptimization;: Symposium of the Institute of Mathematics and Its Applications, University of Keele, England, 1968
1981978-0-12-260720-2Neil FligsteinGoing north, migration of Blacks and whites from the South, 1900-1950 (Quantitative studies in social relations)
1982978-0-12-260740-0Ana FlisserCysticercosis: Present state of knowledge and perspectives: proceedings of an International Workshop on Cysticercosis held in San Miguel de Allende, Guanajuato, Mexico, on November 16-18, 1981
1974978-0-12-260750-9Gesellschaft fur Biologische ChemieGlutathione: Proceedings of the 16th conference of the German Society of Biological Chemistry, Tubingen, March 1973
1972978-0-12-260801-8Klaus FloreyAnalytical Profiles of Drug Substances (v. 1)
1973978-0-12-260802-5Author UnknownProfiles of Drug Substances, Excipients and Related Methodology vol 2, Volume 2 (v. 2)
1974978-0-12-260803-2Klaus FloreyAnalytical Profiles of Drug Substances (v. 3)
1975978-0-12-260804-9   ''Analytical Profiles of Drug Substances: v. 4 (Academic Press rapid manuscript reproduction)
1976978-0-12-260805-6Author UnknownProfiles of Drug Substances, Excipients and Related Methodology vol 5, Volume 5 (v. 5)
1977978-0-12-260806-3Klaus FloreyProfiles of Drug Substances, Excipients and Related Methodology, Vol. 6
1978978-0-12-260807-0Author UnknownFlorey Drug Substance V7
1979978-0-12-260808-7   ''Profiles of Drug Substances, Excipients and Related Methodology vol 8, Volume 8 (v. 8)
1980978-0-12-260809-4   ''Profiles of Drug Substances, Excipients and Related Methodology vol 9, Volume 9 (v. 9)
1981978-0-12-260810-0Klaus FloreyAnalytical Profiles of Drug Substances and Excipients, Volume 10 (Analytical Profiles of Drug Substances & Excipients)
1982978-0-12-260811-7Author UnknownProfiles of Drug Substances, Excipients and Related Methodology vol 11, Volume 11 (Analytical Profiles of Drug Substances & Excipients)
1983978-0-12-260812-4Klaus FloreyAnalytical Profiles of Drug Substances: 12 (Analytical Profiles of Drug Substances & Excipients)
1984978-0-12-260813-1   ''Profiles of Drug Substances, Excipients and Related Methodology (Analytical Profiles of Drug Substances, Excipients, and Related Methodology, Vol. 13)
1985978-0-12-260814-8Author UnknownProfiles of Drug Substances, Excipients and Related Methodology vol 14, Volume 14 (Analytical Profiles of Drug Substances & Excipients)
1986978-0-12-260815-5Author UnknownProfiles of Drug Substances, Excipients and Related Methodology vol 15, Volume 15 (Analytical Profiles of Drug Substances & Excipients)
1987978-0-12-260816-2   ''Profiles of Drug Substances, Excipients and Related Methodology vol 16, Volume 16 (Analytical Profiles of Drug Substances & Excipients)
1988978-0-12-260817-9   ''Profiles of Drug Substances, Excipients and Related Methodology vol 17, Volume 17 (Analytical Profiles of Drug Substances & Excipients)
1990978-0-12-260818-6Klaus FloreyProfiles of Drug Substances, Excipients and Related Methodology (Analytical Profiles of Drug Substances, Excipients, and Related Methodology, Vol. 18)
1991978-0-12-260819-3Author UnknownProfiles of Drug Substances, Excipients and Related Methodology vol 19, Volume 19 (Analytical Profiles of Drug Substances & Excipients)
  ''978-0-12-260820-9Klaus Florey · Harry G. Brittain · David J. Mazzo · Timothy J. Wozniak · Gerald S. Brenner · George A. Forcier · Abdullah A. Al-BadrAnalytical Profiles of Drug Substances and Excipients (Volume 20) (Analytical Profiles of Drug Substances (Volume 20))
1992978-0-12-260821-6Harry G. BrittainAnalytical Profiles of Drug Substances and Excipients, Vol. 21
1993978-0-12-260822-3   ''Analytical Profiles of Drug Substances and Excipients, Volume 22
1994978-0-12-260823-0   ''Analytical Profiles of Drug Substances and Excipients, Volume 23 (Analytical Profiles of Drug Substances & Excipients)
1996978-0-12-260824-7Harry G. BrittainAnalytical Profiles of Drug Substances and Excipients, Volume 24 (Analytical Profiles of Drug Substances & Excipients)
1998978-0-12-260825-4   ''Analytical Profiles of Drug Substances and Excipients (Volume 25)
1999978-0-12-260826-1   ''Analytical Profiles of Drug Substances and Excipients (Volume 26)
2001978-0-12-260827-8   ''Analytical Profiles of Drug Substances and Excipients (Volume 27)
  ''978-0-12-260828-5   ''Analytical Profiles of Drug Substances and Excipients (Volume 28)
2002978-0-12-260829-2Harry G. BrittainAnalytical Profiles of Drug Substances and Excipients (Volume 29)
2004978-0-12-260830-8   ''Profiles of Drug Substances, Excipients and Related Methodology, Volume 30
2005978-0-12-260831-5   ''Profiles of Drug Substances, Excipients and Related Methodology, Volume 31
2006978-0-12-260832-2   ''Profiles of Drug Substances, Excipients and Related Methodology, Volume 32
2007978-0-12-260833-9   ''Profiles of Drug Substances, Excipients and Related Methodology, Volume 33: Critical Compilation of pKa Values for Pharmaceutical Substances
1960978-0-12-261001-1MARCEL & H MASON FLORKINComparative Biochemistry Volume 1 Free Energ
978-0-12-261002-8Comparative Biochemistry: v. 2
1962978-0-12-261004-2Marcel · Mason, Howard S. FlorkinComparative Biochemistry: v. 4
1968978-0-12-261031-8Marcel / Bradley T. Scheer, Editors FlorkinChemical Zoology, Volume Ii, Porifera, Coelenterata, Platyhelminthes
978-0-12-261032-5Chemical Zoology: v. 2
1969978-0-12-261033-2Marcel Florkin · Bradley T. ScheerChemical Zoology, Vol. 3: Echinodermata, Nematoda, and Acanthocephala
  ''978-0-12-261034-9Marcel FlorkinChemical Zoology, Vol. 4: Annelida, Echiura, and Sipuncula
1967978-0-12-261035-6Marcel FlorkinChemical Zoology, Vol. 5: Arthropoda, Part A
1969978-0-12-261036-3Marcel Florkin: Bradley T. ScheerChemical Zoology
1967978-0-12-261037-0M. and Scheer, B. T. (eds.) FlorkinChemical Zoology
1974978-0-12-261038-7Marcel Florkin · Bradley T. ScheerChemical Zoology, Vol. 8: Deuterostomians, Cyclostomes and Fishes
  ''978-0-12-261039-4   ''Chemical Zoology, Vol. 9: Amphibia and Reptilia
1978978-0-12-261040-0Marcel FlorkinChemical Zoology, Vol. 10: Aves
1979978-0-12-261041-7   ''Chemical Zoology, Vol. 11: Mammalia
1969978-0-12-261046-2Marcel and Ernest Schoffeniels. FlorkinMolecular Approaches to Ecology.
1976978-0-12-261201-5V I [Eds] Goldanskii · E FluckModern physics in chemistry (v. 1)
1979978-0-12-261202-2E. Fluck · V. I. GoldanskiiModern Physics in Chemistry, Vol. 2
1997978-0-12-261206-0Clif FlyntTCL/TK for Real Programmers
1992978-0-12-261310-4Uriel G. Foa · Kjell Y. Tornblum · Eda B. FoaResource Theory: Explorations and Applications
1982978-0-12-261320-3James L. FobesPrimate Behavior (Communication and behavior)
1978978-0-12-261350-0L.J. FolinsbeeEnvironmental stress: Individual human adaptations
1994978-0-12-261520-7Guido Forni · Robin Foa · Angela Santoni · David QuinnCytokine-Induced Tumor Immunogenicity: From Exogenous Molecules to Gene Therapy
1977978-0-12-261550-4Raymond D. Fogelson · Richard N. AdamsThe Anthropology of power: Ethnographic studies from Asia, Oceania, and the New World (Studies in anthropology)
1973978-0-12-261650-1G.E. FoggThe Blue-green algae
1963978-0-12-261702-7Wilhelm FoerstNewer Methods of Preparative Organic Chemistry. Vol.2
1965978-0-12-261703-4W FoerstNewer Methods of Preparative Organic Chemistry: v. 3
1968978-0-12-261704-1Wilhelm FoerstNewer Methods of Preparative Organic Chemistry: v. 4
  ''978-0-12-261705-8W FoerstNewer Methods of Preparative Organic Chemistry, (Vol. V)
1971978-0-12-261706-5W . FoerstNewer Methods of Preparative Organic Chemistry: v. 6
1973978-0-12-261850-5Jørgen FoghContamination in tissue culture,
1978978-0-12-261860-4Jorgen FoghThe Nude Mouse in Experimental and Clinical Research (v. 1)
1982978-0-12-261862-8Jorgen RoghThe Nude Mouse in Experimental and Clinical Research
1983978-0-12-261880-2William J. Folan · Ellen R. Kintz · Laraine A. FletcherCoba: A Classic Maya Metropolis (Studies in Archaeology)
1997978-0-12-261910-6Todd FoleyWindows NT Server Training Guide
  ''978-0-12-261911-3Author UnknownWindows NT Guide ***Replacement*** CD-ROM
2002978-0-12-261912-0Henry C. FoleyIntroduction to Chemical Engineering Analysis Using Mathematica
1996978-0-12-261915-1Todd FoleyThe Microsoft Exchange Guide
1984978-0-12-261920-5Robert FoleyHominid Evolution and Community Ecology: Prehistoric Human Adaptation in Biological Perspective (Studies in Archaeology)
978-0-12-261931-1Human Diversity Vol 1
978-0-12-261932-8Human Diversity Vol 2
978-0-12-261933-5Human Diversity Vol 3
978-0-12-261934-2Human Diversity Vol 4
1969978-0-12-261950-2Karl W. FolleySemigroups
1986978-0-12-261970-0Samuel J., M.D. FomonEnergy and Protein Needs During Infancy (Bristol-myers Squibb Nutrition Symposia)
1982978-0-12-262020-1Peter FontanaAtomic Radiative Processes (Pure and applied physics)
1983978-0-12-262040-9A. Fontijn · M.A.A. ClyneReactions of Small Transient Species: Kinetics and Energetics
1968978-0-12-262050-8A.R., J.M. Hay, and R.H. Thomson ForresterOrganic Chemistry of Stable Free Radicals
1990978-0-12-262140-6David FordUnderstanding Business Markets: Interaction, Relationships and Networks
  ''978-0-12-262141-3David FordUnderstanding Business Markets: Interaction, Relationships, Networks
1973978-0-12-262150-5Edward Hugh Rawlinson FordHuman chromosomes
1980978-0-12-262161-1FordhamAnalytical Psychology: A Modern Science (Library of Analytical Psychology)
1980978-0-12-262162-8Michael Fordham · Rosemary Gordon · Judith Hubback · LambertTechniques in Jungian Analysis
1986978-0-12-262164-2Michael FordhamExplorations into the Self (Library of Analytical Psychology, Vol 7)
1987978-0-12-262165-9William ForesterInternational Perspectives on Hazardous Waste Management: A Report from the International Solid Wastes and Public Cleansing Association (Iswa Worki)
1992978-0-12-262170-3William S. ForesterWaste Minimization and Clean Technology: Waste Management Strategies for the Future
1993978-0-12-262210-6John C. Foreman · Clive PageImmunopharmacology of Mast Cells and Basophils (Handbook of Immunopharmacology)
1982978-0-12-262220-5George E. FormanAction and thought: From sensorimotor schemes to symbolic operations (Developmental psychology series)
1975978-0-12-262250-2Meyer Fortes · Sheila PattersonStudies in African social anthropology
1995978-0-12-262270-0Ronald N. Forthofer · Eun Sul LeeIntroduction to Biostatistics: A Guide to Design, Analysis and Discovery.
1985978-0-12-262301-1D. L. Forrest-Pressley · G. E. MacKinnonMetacognition, Cognition, and Human Performance: Theoretical Perspectives
  ''978-0-12-262302-8   ''Metacognition, Cognition, and Human Performance: Instructional Practices
1998978-0-12-262340-0Joseph ForshawEncyclopedia of Birds, Second Edition (Natural World)
1973978-0-12-262350-9Wendell ForstTheory of unimolecular reactions (Physical chemistry, a series of monographs)
1981978-0-12-262360-8Othmar Forster · Maurice LandyHeterogeneity of mononuclear phagocytes
1994978-0-12-262430-8Donald E. FosketPlant Growth and Development: A Molecular Approach
2002978-0-12-262432-2D. FosketPlant Growth and Development
1981978-0-12-262501-5Henry FosterThe Mouse in Biomedical Research (Vol. I): History, Genetics, and Wild Mice
1982978-0-12-262502-2Henry L. Foster · J. David Small · James G. FoxThe Mouse in Biomedical Research: Diseases
1983978-0-12-262503-9Henry Foster · J. David Small · James G. FoxThe Mouse in Biomedical Research (Vol. III): Normative Biology, Immunology and Husbandry
1982978-0-12-262504-6Author UnknownThe Mouse in Biomedical Research, Volume 4 (American College of Laboratory Animal Medicine)
1976978-0-12-262550-3Trevor David Ford · Cecil Howard Dunstan CullingfordThe Science of speleology
1969978-0-12-262650-0R FosterOrganic charge-transfer complexes (Organic chemistry; a series of monographs)
1992978-0-12-262660-9C. L. FosterAlgorithms, Abstraction and Implementation: Levels of Detail in Cognitive Science (Cognitive Science Series)
1980978-0-12-262680-7Mary Lecron Foster · Stanley H. BrandesSymbol As Sense: New Approaches to the Analysis of Meaning (Language, thought, and culture)
1975978-0-12-262701-9Roy FosterMolecular Association Including Molecular Complexes, Vol. 1
1979978-0-12-262702-6Roy FosterMolecular association: Including molecular complexes (v. 2)
1969978-0-12-262801-6Leslie FouldsNeoplastic Development, Vol. 1
1975978-0-12-262802-3   ''Neoplastic Development: v. 2
1994978-0-12-262850-4Efi Foufoula-Georgiou · Praveen KumarWavelets in Geophysics (Volume 4) (Wavelet Analysis and Its Applications (Volume 4))
978-0-12-262901-3Immunology, Nineteen Eighty, 1 (v. 1)
978-0-12-262902-0Four International Congress of Immunology, Immunology 80, Volume 2 (v. 2)
1981978-0-12-262903-7Immunology, Nineteen Eighty, Vol. 3
978-0-12-262940-2Immunology Eighty: Progress in Immunology IV (Fourth International Congress of Immunology)
2000978-0-12-262942-6Nicholas FourikisAdvanced Array Systems, Applications and RF Technologies (Signal Processing and its Applications)
1987978-0-12-262945-7Terry J. FountainProcessor Arrays: Architecture and Applications (Microelectronics and Signal Processing Series)
1968978-0-12-262950-1Beall W FowlerPhysics of Color Centers
1963978-0-12-263150-4Lewis FowlerFourth International Symposium on Gas Chromatography
1976978-0-12-263250-1G. A. FouldsThe Hierarchical Nature of Personal Illness
2008978-0-12-263300-3UnknownREVISTA ENUNCIACION #13 ENSEÃANZA Y APRENDIZAJE DE LA LENGUA
1979978-0-12-263350-8George FosterLong Term Field Research in Social Anthropology (Studies in anthropology)
  ''978-0-12-263450-5Richard T.T. FormanPine barrens: Ecosystem and landscape
1980978-0-12-263550-2Joseph ForgasSocial Episodes: The Study of Interaction Routines (European monographs in social psychology)
1982978-0-12-263560-1Joseph ForgasSocial Cognition: Perspectives on Everyday Understanding (European Monographs in Social Psychology)
1982978-0-12-263562-5Joseph ForgasSocial Cognition (European Monographs in Social Psychology)
1994978-0-12-263590-8Author UnknownThe GUI Style Guide
1984978-0-12-263620-2James G. Fox · Bennett J. CohenLaboratory Animal Medicine (American College of Laboratory Animal Medicine Series)
1972978-0-12-263650-9C. Fred (Ed) FoxMembrane Research
2004978-0-12-263651-6Patrick F. Fox · Paul L.H. McSweeney · Timothy M. Cogan · Timothy P. GuineeCheese: Chemistry, Physics & Microbiology, Two-Volume Set, Volume 1-2, Third Edition
  ''978-0-12-263652-3Patrick F. Fox · Paul L. H. McSweeney · Timothy M. Cogan · Timothy P. GuineeCheese: Chemistry, Physics and Microbiology, Volume 1: General Aspects
  ''978-0-12-263653-0   ''Cheese: Chemistry, Physics & Microbiology, Vol. 2: Major Cheese Groups
1973978-0-12-263660-8C.Fred Fox · William Sydney RobinsonVirus research;: [proceedings]
1966978-0-12-263850-3john foxIsobaric Spin in Nuclear Physics
1981978-0-12-263950-0James Alan FoxModels in Quantitative Criminology (Quantitative Studies in Social Relations)
2002978-0-12-263951-7James G. Fox · Lynn C. Anderson · Franklin M. Loew · Fred W. QuimbyLaboratory Animal Medicine (American College of Laboratory Animal Medicine)
1981978-0-12-263952-4James Alan FoxMethods in Quantitative Criminology (Quantitative studies in social relations)
1965978-0-12-264250-0Sidney W. (ed.) FoxThe Origins of Prebiological Systems and of Their Molecular Matrices; Proceedings of a Conference Conducted at Wakulla Spring
1979978-0-12-264280-7H. FoxChange in the Countryside: Essays on Rural England, 1500-1900 (INSTITUTE OF BRITISH GEOGRAPHERS SPECIAL PUBLICATIONS)
1980978-0-12-264650-8Charles H FuchsmanPeat, industrial chemistry and technology
  ''978-0-12-264750-5Norman FreemanStrategies of Representation in Young Children
1997978-0-12-264840-3Richard S.J. Frackowiak · Karl J. Friston · Christopher D. Frith · Raymond J. Dolan · John C. MazziottaHuman Brain Function
2004978-0-12-264841-0Richard S.J. Frackowiak · John T. Ashburner · William D. Penny · Semir ZekiHuman Brain Function, Second Edition
1979978-0-12-264850-2Maurice Fran-ConOptical Image Formation and Processing (English and French Edition)
1996978-0-12-265040-6Joachim FrankThree-Dimensional Electron Microscopy of Macromolecular Assemblies
1978978-0-12-265050-5Robert H. Frank · Richard T. FreemanDistributional Consequences of Direct Foreign Investment (Economic Theory, Econometrics, and Mathematical Economics)
1969978-0-12-265150-2Heinz Fraenkel-ConratThe Chemistry and Biology of Viruses
1962978-0-12-265162-5H. Fraenkel-ConratDesign And Function At The Threshold Of Life: The Viruses
  ''978-0-12-265168-7Heinz Fraenkel-ConratDesign and Function at the Threshold of Life: The Viruses
978-0-12-265169-4Francisco · ShephsonFundamentals of Atmospheric Chemistry
1978978-0-12-265250-9G.W. Frankie · C.S. KoehlerPerspectives in urban entomology
1981978-0-12-265280-6Paul Franchimont · Cornelia P. ChanningIntragonadal regulation of reproduction
2000978-0-12-265320-9Colin E.C. Wood · A. G. Perera · Deborah Taylor · Phillip Broussard · J. D. Adam · Maurice H. FrancombeHandbook of Thin Film Devices, Five-Volume Set, Volume 1-5: Frontiers of Research, Technology, and Applications
2000978-0-12-265340-7Luc Frappat · Antonino Sciarrino · Paul SorbaDictionary on Lie Algebras and Superalgebras
1978978-0-12-265350-6Kenneth Boyd FraserMeasles virus and its biology (Experimental virology)
1977978-0-12-265450-3Fay FransellaA manual for repertory grid technique
  ''978-0-12-265456-5Fay FransellaA Manual for Repertory Grid Technique
1978978-0-12-265460-2   ''Personal construct psychology, 1977
1977978-0-12-265550-0Alfred White FranklinChallenge of Child Abuse
1982978-0-12-265620-0Susan FrankGlass and archaeology (Studies in archaeological science)
1978978-0-12-265650-7Paul M FrankIntroduction to system sensitivity theory
2006978-0-12-265655-2Giorgio Franceschetti · Daniele RiccioScattering, Natural Surfaces, and Fractals
1974978-0-12-265750-4M FrançonHolography;
1979978-0-12-265760-3M. FranconLaser Speckle and Application in Optics
1976978-0-12-265850-1Bruce FraserThe verb-particle combination in English (Taishukan studies in modern linguistics)
1975978-0-12-265950-8Joseph F. FraumeniPersons at high risk of cancer: An approach to cancer etiology and control: proceedings of a conference, Key Biscayne, Florida, December 10-12, 1974
1973978-0-12-266050-4B. Don FranksEvaluating Performance in Physical Education
2003978-0-12-266051-1George Frankfurter · Bob G. Wood · James WansleyDividend Policy: Theory and Practice
1996978-0-12-266070-2Keith B.J. Franklin · George PaxinosThe Mouse Brain in Sterotaxic Coordinates
1972978-0-12-266150-1Fay FransellaPersonal change and reconstruction;: Research on a treatment of stuttering
1997978-0-12-266170-9Valery J. FrantsAutomated Information Retrieval (Library and Information Science) (Library and Information Science)
1971978-0-12-266250-8T. J FranklinBiochemistry of antimicrobial action
1979978-0-12-266260-7L.M. FranksNeoplastic transformation in differentiated epithelial cell systems in vitro
1966978-0-12-266350-5Maurice FranconOptical Interferometry
1968978-0-12-266450-2A.F. FraserReproductive Behaviour in Ungulates
1981978-0-12-266501-1Robert B. Freedman · Hilary C. HawkinsThe Enzymology of Post-Translational Modification of Proteins (Molecular Biology,)
1985978-0-12-266502-8Robert B. FreedmanThe Enzymology of Post Translational Modification of Proteins (Molecular Biology)
1989978-0-12-266540-0Bill FreedmanEnvironmental Ecology: The Impacts of Pollution and Other Stresses on Ecosystem Structure and Function
1994978-0-12-266541-7Bill FreedmanEnvironmental Ecology: The Ecological Effects Of Pollution, Disturbance, And Other Stresses
  ''978-0-12-266542-4   ''Environmental Ecology: The Ecological Effects of Pollution, Disturbance, and Other Stresses
1968978-0-12-266550-9Jonathan L. Freedman · Anthony N. DoobDeviancy: The Psychology of Being Different
1970978-0-12-266650-6John Brand FreeInsect pollination of crops,
1993978-0-12-266651-3   ''Insect Pollination of Crops
1974978-0-12-266701-5Arthur J FreemanThe actinides: electronic structure and related properties, (Materials science series) (v. 1)
  ''978-0-12-266702-2A.J. And J.B. Darby, Jr. (Editors) FreemanThe Actinides: Electronic Structure and Related Properties Vol. 2
1989978-0-12-266719-0Herbert FreemanMachine Vision for Inspection and Measurement (Perspectives in Computing)
1988978-0-12-266720-6Herbert FreemanMachine Vision: Algorithms, Architectures, and Systems (Perspectives in Computing)
1990978-0-12-266722-0Herbert FreemanMachine Vision for Three Dimensional Scenes
1967978-0-12-266750-3Arthur J., and Richard B. Frankel FreemanHyperfine Interactions
1972978-0-12-266950-7Walter FreibergerStatistical computer performance evaluation
1989978-0-12-266970-5EMIL, ED. FREIThe Regulation Of Proliferation & Differentiation In Notmal
1994978-0-12-266975-0Balz FreiNatural Antioxidants in Human Health and Disease